Unconstrained Homooligomeric 纬-Peptides Show High Propensity for C14 Helix Formation

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• 作者：Krishnayan Basuroy ; Bhimareddy Dinesh ; M. B. Madhusudana Reddy ; Siddapa Chandrappa ; Srinivasarao Raghothama ; Narayanaswamy Shamala ; Padmanabhan Balaram
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：September 20, 2013
• 年：2013
• 卷：15
• 期：18
• 页码：4866-4869
• 全文大小：225K
• 年卷期：v.15,no.18(September 20, 2013)
• ISSN：1523-7052

文摘

Monosubstituted 纬⁴-residues (纬⁴Leu, 纬⁴Ile, and 纬⁴Val) form helices even in short homooligomeric sequences. C₁₄ helix formation is established by X-ray diffraction in homooligomeric (纬)_n tetra-, hexa- and decapeptide sequences demonstrating the high propensity of 纬 residues, with proteinogenic side chains, to adopt locally folded conformations.