A Green and Facile Approach for Synthesis of Nitro Heteroaromatics in Water

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• 作者：Xiu X. Zhao ; Ji C. Zhang ; Sheng H. Li ; Qing P. Yang ; Yu C. Li ; Si P. Pang
• 刊名：Organic Process Research & Development
• 出版年：2014
• 出版时间：July 18, 2014
• 年：2014
• 卷：18
• 期：7
• 页码：886-890
• 全文大小：252K
• ISSN：1520-586X

文摘

A convenient and green method for the oxidation of nitrogen-rich heterocyclic amines to nitro-substituted heteroaromatics using potassium peroxymonosulfate (2KHSO₅路KHSO₄路K₂SO₄, Oxone) in water was developed. This method has several advantages over previous methods: operational simplicity, safety, inexpensive reagents, the use of H₂O as the sole solvent, and mild conditions. The utility of the present oxidative system was demonstrated by the synthesis of the important energetic compounds 3,4,5-trinitro-1H-pyrazole (TNP) and 5-amino-3-nitro-1H-1,2,4-triazole (ANTA).