Triterpenoids with Promoting Effects on the Differentiation of PC12 Cells from the Steamed Roots of Panax notoginseng
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- 作者：Cheng-Zhen Gu ; Jun-Jiang Lv ; Xiao-Xia Zhang ; Yi-Jun Qiao ; Hui Yan ; Yan Li ; Dong Wang ; Hong-Tao Zhu ; Huai-Rong Luo ; Chong-Ren Yang ; Min Xu ; Ying-Jun Zhang
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：August 28, 2015
- 年：2015
- 卷：78
- 期：8
- 页码：1829-1840
- 全文大小：412K
- ISSN：1520-6025
文摘
The roots of Panax notoginseng, an important Chinese medicinal plant, have been used traditionally in both the raw and processed forms, due to the different chemical constituents and bioactivities found. Thirty-eight dammarane-type triterpenoid saponins were isolated from the steam-processed roots of P. notoginseng, including 18 new substances, namely, notoginsenosides SP1鈥揝P18 (1鈥?b>18). The structures of 1鈥?b>18 were determined on the basis of spectroscopic analysis and acidic hydrolysis. The absolute configuration of the hydroxy group at C-24 in 1鈥?b>4, 19, and 20 was determined in each case by Mo2(AcO)4-induced circular dichroism. The new compounds were found to feature a diversity of highly oxygenated side chains, formed by hydrolysis of the C-20 sugar moiety followed by dehydration, dehydrogenation, epoxidation, hydroxylation, or methoxylation of the main saponins in the raw roots. The new saponins 1, 2, 6鈥?b>8, 14, and 17 and the known compounds 20鈥?b>27 showed promoting effects on the differentiation of PC12 cells, at a concentration of 10 渭M.