Ternifolide A, a New Diterpenoid Possessing a Rare Macrolide Motif from Isodon ternifolius
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- 作者：Juan Zou ; Xue Du ; Guo Pang ; Yi-Ming Shi ; Wei-Guang Wang ; Rui Zhan ; Ling-Mei Kong ; Xiao-Nian Li ; Yan Li ; Jian-Xin Pu ; Han-Dong Sun
- 刊名：Organic Letters
- 出版年：2012
- 出版时间：June 15, 2012
- 年：2012
- 卷：14
- 期：12
- 页码：3210-3213
- 全文大小：266K
- 年卷期：v.14,no.12(June 15, 2012)
- ISSN：1523-7052
文摘
Ternifolide A (1), a new diterpenoid featuring a unique 10-membered lactone ring formed between C-6 and C-15, along with ternifolide B (2), a nor-diterpenoid, and ternifolide C (3) were isolated from the leaves of Isodon ternifolius. Both H-8 and H-9 being 伪-orientations in compound 1 were found for the first time. The absolute configurations of 1 and 3 were confirmed by X-ray diffraction study. Compounds 1 and 3 were evaluated for their cytotoxicity.