Synthesis and Characterization of fac-[M(CO)3(P)(OO)] and cis-trans-[M(CO)2(P)2(OO)] Complexes (M = Re, 99mTc) with Acetylacetone and Curcumin
详细信息 查看全文
- 作者：Charalampos Triantis ; Theodoros Tsotakos ; Charalampos Tsoukalas ; Marina Sagnou ; Catherine Raptopoulou ; Aris Terzis ; Vassilis Psycharis ; Maria Pelecanou ; Ioannis Pirmettis ; Minas Papadopoulos
- 刊名：Inorganic Chemistry
- 出版年：2013
- 出版时间：November 18, 2013
- 年：2013
- 卷：52
- 期：22
- 页码：12995-13003
- 全文大小：451K
- 年卷期：v.52,no.22(November 18, 2013)
- ISSN：1520-510X
文摘
The synthesis and characterization of neutral mixed ligand complexes fac-[M(CO)3(P)(OO)] and cis-trans-[M(CO)2(P)2(OO)] (M = Re, 99mTc), with deprotonated acetylacetone or curcumin as the OO donor bidentate ligands and a phosphine (triphenylphosphine or methyldiphenylphosphine) as the monodentate P ligand, is described. The complexes were synthesized through the corresponding fac-[M(CO)3(H2O)(OO)] (M = Re, 99mTc) intermediate aqua complex. In the presence of phosphine, replacement of the H2O molecule of the intermediate complex at room temperature generates the neutral tricarbonyl monophosphine fac-[Re(CO)3(P)(OO)] complex, while under reflux conditions further replacement of the trans to the phosphine carbonyl generates the new stable dicarbonyl bisphosphine complex cis-trans-[Re(CO)2(P)2(OO)]. The Re complexes were fully characterized by elemental analysis, spectroscopic methods, and X-ray crystallography showing a distorted octahedral geometry around Re. Both the monophosphine and the bisphosphine complexes of curcumin show selective binding to 尾-amyloid plaques of Alzheimer鈥檚 disease. At the 99mTc tracer level, the same type of complexes, fac-[99mTc(CO)3(P)(OO)] and cis-trans-[99mTc(CO)2(P)2(OO)], are formed introducing new donor combinations for 99mTc(I). Overall, 尾-diketonate and phosphine constitute a versatile ligand combination for Re(I) and 99mTc(I), and the successful employment of the multipotent curcumin as 尾-diketone provides a solid example of the pharmacological potential of this system.