Photoredox Cross-Coupling: Ir/Ni Dual Catalysis for the Synthesis of Benzylic Ethers

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• 作者：Idris Karakaya ; David N. Primer ; Gary A. Molander
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：July 2, 2015
• 年：2015
• 卷：17
• 期：13
• 页码：3294-3297
• 全文大小：370K
• ISSN：1523-7052

文摘

Single-electron transmetalation has emerged as an enabling paradigm for the cross-coupling of C_sp³ hybridized organotrifluoroborates. Cross-coupling of 伪-alkoxymethyltrifluoroborates with aryl and heteroaryl bromides has been demonstrated by employing dual catalysis with a combination of an iridium photoredox catalyst and a Ni cross-coupling catalyst. The resulting method enables the alkoxymethylation of diverse (hetero)arenes under mild, room-temperature conditions.