Synthesis, Characterization, and Biological Evaluation of M(I)(CO)3(NNO) Complexes (M = Re, 99mTc) Conjugated to 2-(4-Aminophenyl)benzothiazole as Potential Breast Cancer Radioph

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• 作者：Stamatia Tzanopoulou ; Ioannis C. Pirmettis ; George Patsis ; Maria Paravatou-Petsotas ; Evangelia Livaniou ; Minas Papadopoulos ; Maria Pelecanou
• 刊名：Journal of Medicinal Chemistry
• 出版年：2006
• 出版时间：September 7, 2006
• 年：2006
• 卷：49
• 期：18
• 页码：5408 - 5410
• 全文大小：593K
• 年卷期：v.49,no.18(September 7, 2006)
• ISSN：1520-4804

文摘

The synthesis and biological evaluation of new M(I)(CO)₃(NNO) (M = Re, ^99mTc) complexes attached to the antitumor agent2-(4-aminophenyl)benzothiazole are reported. The fluorescent rheniumcomplex enters MCF-7 breast cancer cells but does not enter normalHFFF-2 and MRC-5 cells. The analogous radioactive ^99mTc complexproduces fast blood and soft tissue clearance when administered tohealthy mice. These complexes are promising candidates for developingradiopharmaceuticals for imaging (^99mTc) and targeted radiotherapy(¹⁸⁶Re, ¹⁸⁸Re) of breast cancer.