Biaryl Synthesis via Direct Arylation: Establishment of an Efficient Catalyst for Intramolecular Processes

详细信息    查看全文

• 作者：Louis-Charles Campeau ; Mathieu Parisien ; Melissa Leblanc ; and Keith Fagnou
• 刊名：Journal of the American Chemical Society
• 出版年：2004
• 出版时间：August 4, 2004
• 年：2004
• 卷：126
• 期：30
• 页码：9186 - 9187
• 全文大小：69K
• 年卷期：v.126,no.30(August 4, 2004)
• ISSN：1520-5126

文摘

In this Communication, we describe direct arylation reactions with improved scope and catalyst activity for the intramolecular formation of biaryl compounds. This was achieved through the establishment of a highly active and robust catalyst system and the subsequent development of a novel phosphine ligand 27. The enhanced catalytic activity extends these transformations to include previously unreactive and poorly reactive substrates, and allows for very low catalyst loadings to be employed-as little as 0.1 mol %.