Microbubbles Loaded with Nanoparticles: A Route to Multiple Imaging Modalities

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• 作者：Jai Il Park ; Dinesh Jagadeesan ; Ross Williams ; Wendy Oakden ; Siyon Chung ; Greg J. Stanisz ; Eugenia Kumacheva
• 刊名：ACS Nano
• 出版年：2010
• 出版时间：November 23, 2010
• 年：2010
• 卷：4
• 期：11
• 页码：6579-6586
• 全文大小：452K
• 年卷期：0
• ISSN：1936-086X

文摘

We report a single-step approach to producing small and stable bubbles functionalized with nanoparticles. The strategy includes the following events occurring in sequence: (i) a microfluidic generation of bubbles from a mixture of CO₂ and a minute amount of gases with low solubility in water, in an aqueous solution of a protein, a polysaccharide, and anionic nanoparticles; (ii) rapid dissolution of CO₂ leading to the shrinkage of bubbles and an increase in acidity of the medium in the vicinity of the bubbles; and (iii) co-deposition of the biopolymers and nanoparticles at the bubble−liquid interface. The proposed approach yielded microbubbles with a narrow size distribution, long-term stability, and multiple functions originating from the attachment of metal oxide, metal, or semiconductor nanoparticles onto the bubble surface. We show the potential applications of these bubbles in ultrasound and magnetic resonance imaging.