Alkene-Assisted Nickel-Catalyzed Regioselective 1,4-Addition of Organoboronic Acid to Dienones: A Direct Route to All-Carbon Quaternary Centers

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• 作者：Ya-Chun Hong ; Parthasarathy Gandeepan ; Subramaniyan Mannathan ; Wei-Tse Lee ; Chien-Hong Cheng
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 6, 2014
• 年：2014
• 卷：16
• 期：11
• 页码：2806-2809
• 全文大小：305K
• 年卷期：v.16,no.11(June 6, 2014)
• ISSN：1523-7052

文摘

A nickel-catalyzed highly regioselective 1,4-addition reaction of boronic acids to dienones to form products with an all-carbon quaternary center is described. The 3-alkenyl group of dienones is the key for the reaction to proceed smoothly. A mechanism involving the coordination of the dienyl group to the nickel center is proposed.