Prototypes of Lanthanide(III) Agents Responsive to Enzymatic Activities in Three Complementary Imaging Modalities: Visible/Near-Infrared Luminescence, PARACEST-, and T1-MRI

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• 作者：Jiefang He ; Célia S. Bonnet ; Svetlana V. Eliseeva ; Sara Lacerda ; Thomas Chauvin ; Pascal Retailleau ; Frederic Szeremeta ; Bernard Badet ; Stéphane Petoud ; Éva Tóth ; Philippe Durand
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：March 9, 2016
• 年：2016
• 卷：138
• 期：9
• 页码：2913-2916
• 全文大小：312K
• ISSN：1520-5126

文摘

We report first prototypes of responsive lanthanide(III) complexes that can be monitored independently in three complementary imaging modalities. Through the appropriate choice of lanthanide(III) cations, the same reactive ligand can be used to form complexes providing detection by (i) visible (Tb³⁺) and near-infrared (Yb³⁺) luminescence, (ii) PARACEST- (Tb³⁺, Yb³⁺), or (iii) T₁-weighted (Gd³⁺) MRI. The use of lanthanide(III) ions of different natures for these imaging modalities induces only a minor change in the structure of complexes that are therefore expected to have a single biodistribution and cytotoxicity.