Arene鈥揜uthenium(II) Complexes Containing Inexpensive Tris(dimethylamino)phosphine: Highly Efficient Catalysts for the Selective Hydration of Nitriles into Amides

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• 作者：Roc铆o Garc铆a-脕lvarez ; Josefina D铆ez ; Pascale Crochet ; Victorio Cadierno
• 刊名：Organometallics
• 出版年：2011
• 出版时间：October 24, 2011
• 年：2011
• 卷：30
• 期：20
• 页码：5442-5451
• 全文大小：989K
• 年卷期：v.30,no.20(October 24, 2011)
• ISSN：1520-6041

文摘

The catalytic hydration of nitriles into amides, in water under neutral conditions, has been studied using a series of arene鈥搑uthenium(II) derivatives containing the commercially available and inexpensive ligand tris(dimethylamino)phosphine. Among them, best results were obtained with the complex [RuCl₂(畏⁶-C₆Me₆){P(NMe₂)₃}], which selectively provided the desired amides in excellent yields and short times (TOF values up to 11鈥?00 h^鈥?). The process was operative with both aromatic, heteroaromatic, aliphatic, and 伪,尾-unsaturated organonitriles and showed a high functional group tolerance. The stability of [RuCl₂(畏⁶-C₆Me₆){P(NMe₂)₃}] in water was evaluated, observing its progressive decomposition into the less-active dimethylamine鈥搑uthenium(II) complex [RuCl₂(畏⁶-C₆Me₆)(NHMe₂)] by hydrolysis of the coordinated P(NMe₂)₃ ligand. The X-ray crystal structure determination of the toluene complex [RuCl₂(畏⁶-C₆H₅Me){P(NMe₂)₃}] is also included.