Block Copolymer Membranes for Efficient Capture of a Chemotherapy Drug

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• 作者：X. Chelsea Chen ; Hee Jeung Oh ; Jay F. Yu ; Jeffrey K. Yang ; Nikos Petzetakis ; Anand S. Patel ; Steven W. Hetts ; Nitash P. Balsara
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：August 16, 2016
• 年：2016
• 卷：5
• 期：8
• 页码：936-941
• 全文大小：543K
• 年卷期：0
• ISSN：2161-1653

文摘

We introduce the use of block copolymer membranes for an emerging application, “drug capture”. The polymer is incorporated in a new class of biomedical devices, referred to as ChemoFilter, which is an image-guided temporarily deployable endovascular device designed to increase the efficacy of chemotherapy-based cancer treatment. We show that block copolymer membranes consisting of functional sulfonated polystyrene end blocks and a structural polyethylene middle block (S-SES) are capable of capturing doxorubicin, a chemotherapy drug. We focus on the relationship between morphology of the membrane in the ChemoFilter device and efficacy of doxorubicin capture measured in vitro. Using small-angle X-ray scattering and cryogenic scanning transmission electron microscopy, we discovered that rapid doxorubicin capture is associated with the presence of water-rich channels in the lamellar-forming S-SES membranes in aqueous environment.