Synthesis of the Macrocyclic Core of Leiodermatolide

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• 作者：Ian Paterson ; Tanya Paquet ; Stephen M. Dalby
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：August 19, 2011
• 年：2011
• 卷：13
• 期：16
• 页码：4398-4401
• 全文大小：805K
• 年卷期：v.13,no.16(August 19, 2011)
• ISSN：1523-7052

文摘

The macrocyclic core (2) of the marine macrolide leiodermatolide (1) has been synthesized in 19 steps through a convergent strategy exploiting boron aldol methodology to install the requisite stereochemistry and a selective Stille coupling reaction for controlled fragment assembly, followed by a Yamaguchi macrolactonization and carbamate introduction at the C9-OH.