Total Synthesis of Alotaketal A

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• 作者：Mengyang Xuan ; Ian Paterson ; Stephen M. Dalby
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：November 2, 2012
• 年：2012
• 卷：14
• 期：21
• 页码：5492-5495
• 全文大小：319K
• 年卷期：v.14,no.21(November 2, 2012)
• ISSN：1523-7052

文摘

The total synthesis of the cAMP signaling pathway activator (鈭?-alotaketal A is reported. A convergent approach to the unusual alotane sesterterpenoid skeleton was employed, exploiting a remarkable LiDBB-mediated coupling of an (R)-carvone-derived 未-lactone with an allyl bromide side chain, followed by spiroacetalization.