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A new protein pho
sphata
se inhibitor, 19-
epi-okadaic acid, wa
s i
solated from the marine dinoflagellate
Prorocentrum belizeanum. It
s structureand conformation in
solution ha
s been determined, and important difference
s were found when compared with the lead compound okadaicacid. The new metabolite
showed nanomolar activitie
s, and it
s selectivity for PP2A ver
su
s PP1
surpa
sse
s that
shown by okadaic acid 10-fold,making it one of the mo
st
selective inhibitor
s of thi
s cla
ss.