Organoboron-Catalyzed Regio- and Stereoselective Formation of 尾-2-Deoxyglycosidic Linkages
详细信息 查看全文
- 作者：Thomas M. Beale ; Patrick J. Moon ; Mark S. Taylor
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：July 3, 2014
- 年：2014
- 卷：16
- 期：13
- 页码：3604-3607
- 全文大小：310K
- ISSN：1523-7052
文摘
A borinic acid derived catalyst enables regioselective and 尾-selective reactions of 2-deoxy- and 2,6-dideoxyglycosyl chloride donors with pyranoside-derived acceptors having unprotected cis-1,2- and 1,3-diol groups. The use of catalysis to promote a 尾-selective pathway by enhancement of acceptor nucleophilicity constitutes a distinct approach from previous work, which has been aimed at modulating donor reactivity by variation of protective and/or leaving groups.