Bioinspired Antimicrobial and Biocompatible Bacterial Cellulose Membranes Obtained by Surface Functionalization with Aminoalkyl Groups

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• 作者：Susana C.M. Fernandes ; Patrizia Sadocco ; Ana Alonso-Varona ; Teodoro Palomares ; Arantxa Eceiza ; Armando J.D. Silvestre ; I帽aki Mondragon ; Carmen S.R. Freire
• 刊名：ACS Applied Materials & Interfaces
• 出版年：2013
• 出版时间：April 24, 2013
• 年：2013
• 卷：5
• 期：8
• 页码：3290-3297
• 全文大小：493K
• 年卷期：v.5,no.8(April 24, 2013)
• ISSN：1944-8252

文摘

There has been a great deal of interest in the use of nanostructured bacterial cellulose membranes for biomedical applications, including tissue implants, wound healing, and drug delivery. However, as bacterial cellulose does not intrinsically present antimicrobial properties, in the present study, antimicrobial bacterial cellulose membranes were obtained by chemical grafting of aminoalkyl groups onto the surface of its nanofibrillar network. This approach intends to mimic intrinsic antimicrobial properties of chitosan. Interestingly, these novel grafted bacterial cellulose membranes (BC-NH₂) are simultaneously lethal against S. aureus and E. coli and nontoxic to human adipose-derived mesenchymal stem cells (ADSCs) and thus may be useful for biomedical applications. In addition to these biological properties, the bioactive nanostructured BC-NH₂ membranes also present improved mechanical and thermal properties.

Keywords:

bacterial cellulose; aminoalkyl groups; antimicrobial; biocompatibility