Palladium-Catalyzed Alkyne Insertion/Reduction Route to Trisubstituted Olefins

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• 作者：Erin R. Fruchey ; Brendan M. Monks ; Andrea M. Patterson ; Silas P. Cook
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：September 6, 2013
• 年：2013
• 卷：15
• 期：17
• 页码：4362-4365
• 全文大小：275K
• 年卷期：v.15,no.17(September 6, 2013)
• ISSN：1523-7052

文摘

A new route to trisubstituted olefins through a palladium-catalyzed alkyne insertion/reduction reaction with unactivated alkyl iodides is reported. The reaction proceeds under mild conditions and tolerates a range of functional groups and substitution patterns. Preliminary mechanistic inquiry suggests that the transformation may proceed through a hybrid radical/organometallic pathway.