Neoglycoenzyme-Gated Mesoporous Silica Nanoparticles: Toward the Design of Nanodevices for Pulsatile Programmed Sequential Delivery
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- 作者：Paula Díez ; Alfredo Sánchez ; Cristina de la Torre ; María Gamella ; Paloma Martínez-Ruíz ; Elena Aznar ; Ramón Martínez-Máñez ; José M. Pingarrón ; Reynaldo Villalonga
- 刊名：ACS Applied Materials & Interfaces
- 出版年：2016
- 出版时间：March 30, 2016
- 年：2016
- 卷：8
- 期：12
- 页码：7657-7665
- 全文大小：540K
- ISSN：1944-8252
文摘
We report herein the design of a stimulus-programmed pulsatile delivery system for sequential cargo release based on the use of a lactose-modified esterase as a capping agent in phenylboronic acid functionalized mesoporous silica nanoparticles. The dual-release mechanism was based on the distinct stability of the cyclic boronic acid esters formed with lactose residues and the long naturally occurring glycosylation chains in the modified neoglycoenzyme. Cargo delivery in succession was achieved using glucose and ethyl butyrate as triggers.