Elevated 伪-Methyl-纬-hydroxy-1,N2-propano-2鈥?deoxyguanosine Levels in Urinary Samples from Individuals Exposed to Urban Air Pollution

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• 作者：Camila C. M. Garcia ; Flor锚ncio P. Freitas ; Ang茅lica B. Sanchez ; Paolo Di Mascio ; Marisa H. G. Medeiros
• 刊名：Chemical Research in Toxicology
• 出版年：2013
• 出版时间：November 18, 2013
• 年：2013
• 卷：26
• 期：11
• 页码：1602-1604
• 全文大小：225K
• 年卷期：v.26,no.11(November 18, 2013)
• ISSN：1520-5010

文摘

Acetaldehyde and crotonaldehyde are genotoxic aldehydes present in tobacco smoke and vehicle exhaust. The reaction of these aldehydes with 2鈥?deoxyguanosine in DNA produces 伪-methyl-纬-hydroxy-1,N²-propano-2鈥?deoxyguanosine (1,N²-propanodGuo). Online HPLC-tandem mass spectrometry was utilized to accurately quantify 1,N²-propanodGuo in human urinary samples from 47 residents of S茫o Paulo City (SP) and 35 residents of the rural municipality of S茫o Jo茫o da Boa Vista (SJBV) in the state of S茫o Paulo. Significantly higher 1,N²-propanodGuo levels were found in the samples from SP donors than in samples from SJBV donors. Our results provide the first evidence that elevated levels of 1,N²-propanodGuo in urinary samples may be correlated with urban air pollution.