The Pregnancy Exposome: Multiple Environmental Exposures in the INMA-Sabadell Birth Cohort

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• 作者：Oliver Robinson ; Xavier Basaga帽a ; Lydiane Agier ; Montserrat de Castro ; Carles Hernandez-Ferrer ; Juan R. Gonzalez ; Joan O. Grimalt ; Mark Nieuwenhuijsen ; Jordi Sunyer ; R茅my Slama ; Martine Vrijheid
• 刊名：Environmental Science & Technology
• 出版年：2015
• 出版时间：September 1, 2015
• 年：2015
• 卷：49
• 期：17
• 页码：10632-10641
• 全文大小：530K
• ISSN：1520-5851

文摘

The 鈥渆xposome鈥?is defined as 鈥渢he totality of human environmental exposures from conception onward, complementing the genome鈥?and its holistic approach may advance understanding of disease etiology. We aimed to describe the correlation structure of the exposome during pregnancy to better understand the relationships between and within families of exposure and to develop analytical tools appropriate to exposome data. Estimates on 81 environmental exposures of current health concern were obtained for 728 women enrolled in The INMA (INfancia y Medio Ambiente) birth cohort, in Sabadell, Spain, using biomonitoring, geospatial modeling, remote sensors, and questionnaires. Pair-wise Pearson鈥檚 and polychoric correlations were calculated and principal components were derived. The median absolute correlation across all exposures was 0.06 (5th鈥?5th centiles, 0.01鈥?.54). There were strong levels of correlation within families of exposure (median = 0.45, 5th鈥?5th centiles, 0.07鈥?.85). Nine exposures (11%) had a correlation higher than 0.5 with at least one exposure outside their exposure family. Effectively all the variance in the data set (99.5%) was explained by 40 principal components. Future exposome studies should interpret exposure effects in light of their correlations to other exposures. The weak to moderate correlation observed between exposure families will permit adjustment for confounding in future exposome studies.