Direct Catalytic Asymmetric Synthesis of 尾-Hydroxy Acids from Malonic Acid

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• 作者：Hang Gao ; Zhenli Luo ; Pingjin Ge ; Junqian He ; Feng Zhou ; Peipei Zheng ; Jun Jiang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：17
• 期：24
• 页码：5962-5965
• 全文大小：411K
• ISSN：1523-7052

文摘

A nickel(II) catalyzed asymmetric synthesis of 尾-hydroxy acids from malonic acid and ketones was developed, revealing for the first time the synthetic utility of malonic acid in the construction of chiral carboxyl acids; importantly, the synthetic potential of this strategy was further demonstrated by the rapid construction of cephalanthrin A, phaitanthrin B, cruciferane, and rice metabolites.