Tetrahydroxanthones by Sequential Pd-Catalyzed C鈭扥 and C鈭扖 Bond Construction and Use in the Identification of the 鈥淎ntiausterity鈥?Pharmacophore of the Kigamicins

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• 作者：Penelope A. Turner ; Ellanna M. Griffin ; Jacqueline L. Whatmore ; Michael Shipman
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：March 4, 2011
• 年：2011
• 卷：13
• 期：5
• 页码：1056-1059
• 全文大小：718K
• 年卷期：v.13,no.5(March 4, 2011)
• ISSN：1523-7052

文摘

Readily available C-acylated cycloalkanones undergo efficient Pd catalyzed ring closure/cross-coupling providing 7-substituted tetrahydroxanthones in a single operation. One of the synthesized derivatives (depicted) is shown to selectively kill pancreatic cancer (PANC-1) cells under conditions of nutrient deprivation indicating that the tetrahydroxanthone is responsible, in part, for the 鈥渁ntiausterity鈥?effects of the naturally occurring kigamicins.