Exotines A and B, Two Heterodimers of Isopentenyl-Substituted Indole and Coumarin Derivatives from Murraya exotica

详细信息    查看全文

• 作者：Bing-Yu Liu ; Chen Zhang ; Ke-Wu Zeng ; Jun Li ; Xiao-Yu Guo ; Ming-Bo Zhao ; Peng-Fei Tu ; Yong Jiang
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：September 4, 2015
• 年：2015
• 卷：17
• 期：17
• 页码：4380-4383
• 全文大小：284K
• ISSN：1523-7052

文摘

Exotines A and B (1 and 2), two heterodimers of isopentenyl-substituted indole and coumarin derivatives linked through a new fused heptacyclic ring system, were isolated from the roots of Murraya exotica. Their structures were established by comprehensive NMR and MS spectroscopic data analysis, and the absolute configurations were determined by single-crystal X-ray crystallographic analysis and ECD calculations. Compounds 1 and 2 showed inhibition of nitric oxide production in lipopolysaccharide-induced BV-2 microglial cells with IC₅₀ values of 9.2 and 39.9 渭M, respectively.