Sonocrystallization: The Use of Ultrasound for Improved Industrial Crystallization

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• 作者：Graham Ruecroft ; David Hipkiss ; Tuan Ly ; Neil Maxted ; and Peter W. Cains
• 刊名：Organic Process Research & Development
• 出版年：2005
• 出版时间：November 2005
• 年：2005
• 卷：9
• 期：6
• 页码：923 - 932
• 全文大小：687K
• 年卷期：v.9,no.6(November 2005)
• ISSN：1520-586X

文摘

An overview of the application of power ultrasound to crystallization of organic molecules, and the equipment developed inrecent years in which sonocrystallization and sonochemistrymay be carried out at industrial scale, is presented. It includesboth results from the research and development programscarried out by us and a survey of developments in the fieldmore generally. The most important effect of ultrasound oncrystallization is the induction of nucleation and the principalbenefits derived from an ability to manipulate this effect. Thereported effects of ultrasound on crystal nucleation and growthhave been briefly reviewed, and examples are given of physicalproperties of the products having been manipulated by varyingand controlling the insonation regime. New applications, directions, and developments have been identified. Developments inscale-up methods and available equipment have also beenreviewed. It is the availability of robust large-scale equipmentthat has been critical to establishing the viability of thistechnology for industrial use in recent years.