A Catalytic Peterson-like Synthesis of Alkenyl Nitriles
详细信息 查看全文
- 作者：Daniela Lanari ; Matteo Alonzi ; Francesco Ferlin ; Stefano Santoro ; Luigi Vaccaro
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：June 3, 2016
- 年：2016
- 卷：18
- 期：11
- 页码：2680-2683
- 全文大小：348K
- 年卷期：0
- ISSN：1523-7052
文摘
A heterogeneous fluoride catalyst was found to enable the straightforward formation of alkenyl nitriles from the reaction of aldehydes and simple or substituted acetonitriles, in the presence of commercially available silazanes and in solvent-free conditions. The protocol afforded the products in good to excellent yields with selectivity values dependent on the nature of the substrates. It represents an alternative to classic approaches using stoichiometric strong bases, and the catalyst can be easily recovered and reused for consecutive cycles.