Effect of O6-Methylguanine on the Stability of G-Quadruplex DNA
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- 作者：Chongkham S. Mekmaysy ; Luigi Petraccone ; Nichola C. Garbett ; Patricia A. Ragazzon ; Robert Gray ; John O. Trent ; Jonathan B. Chaires
- 刊名：Journal of the American Chemical Society
- 出版年：2008
- 出版时间：May 28, 2008
- 年：2008
- 卷：130
- 期：21
- 页码：6710 - 6711
- 全文大小：430K
- 年卷期：v.130,no.21(May 28, 2008)
- ISSN：1520-5126
文摘
The effects of substitution of O6-methylguanine on the structure and stability of a human telomere quadruplex was studied by circular dichroism, thermal denaturation, analytical ultracentrifugation, and molecular dynamics simulations. The results show that, while quadruplex structures can form containing the modified base, they are much less stable than the normal unmodified structure. The extent of destabilization is critically dependent on the exact position of the modified base within the quadruplex structure.