Biomimetic Total Synthesis of Angelicoin A and B via a Palladium-Catalyzed Decarboxylative Prenylation-Aromatization Sequence

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• 作者：Katie Anderson ; Frederick Calo ; Toni Pfaffeneder ; Andrew J. P. White ; Anthony G. M. Barrett
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：November 4, 2011
• 年：2011
• 卷：13
• 期：21
• 页码：5748-5750
• 全文大小：715K
• 年卷期：v.13,no.21(November 4, 2011)
• ISSN：1523-7052

文摘

Five-step total syntheses of angelicoin A and B from 2,2,6-trimethyl-4-dioxinone are reported using late stage biomimetic aromatization reactions via diketo-dioxinones as intermediates. In addition, with angelicoin A, this aromatization was coupled with a palladium-catalyzed decarboxylative prenylation in a one-pot sequence as the key step.