Rhenium and Technetium Complexes with Pentadentate Thiocarbamoylbenzamidines: Steps toward Bioconjugation

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• 作者：Hung Huy Nguyen ; Chien Thang Pham ; Ulrich Abram
• 刊名：Inorganic Chemistry
• 出版年：2015
• 出版时间：June 15, 2015
• 年：2015
• 卷：54
• 期：12
• 页码：5949-5959
• 全文大小：468K
• ISSN：1520-510X

文摘

Thiocarbamoylbenzimidoyl chlorides, PhC(Cl)鈺怤鈥?C鈺怱)鈥揘R¹R², react with 2-(iminodiacetic acid)benzylamine under formation of the potentially pentadentate ligands H₃L (R¹, R² = Et) and H₃L鈥揅OOEt (R¹ = Me, R² = C₆H₄-4-COOEt) in high yields. Hydrolysis of H₃L鈥揅OOEt in NaOH/MeOH gives quantitatively another benzamidine ligand H₃L鈥揅OOH. The novel ligands readily react with (NBu₄)[MOCl₄] (M = Re, Tc) under formation of stable complexes with the general composition [MO(L)], in which they are triply deprotonated and fully occupy the remaining five coordination positions of the {MO}³⁺ cores. In a 鈥減roof-of-principle鈥?reaction for possible bioconjugations, the complex [ReO(L鈥揅OOH)] has been labeled with triglycine ethyl ester in high yields.