Magnesium Increases the Curvature of Duplex DNA That Contains dA Tracts

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• 作者：Bozidar Jerkovic and Philip H. Bolton
• 刊名：Biochemistry
• 出版年：2001
• 出版时间：August 7, 2001
• 年：2001
• 卷：40
• 期：31
• 页码：9406 - 9411
• 全文大小：55K
• 年卷期：v.40,no.31(August 7, 2001)
• ISSN：1520-4995

文摘

Distinct structural features of DNA, such as the curvature of dA tracts, are important in therecognition, packaging, and regulation of DNA. Physiologically relevant concentrations of magnesiumhave been found to enhance the curvature of dA tract DNAs, as monitored by solution-state NMR, indicatingthat the structure of DNA depends on the cations present in solution. A model is presented which accountsfor the sequence-dependent effects of magnesium on DNA curvature as well as for the previously knownsequence-independent effect on DNA flexibility.