Solid Lipid Nanoparticles for Image-Guided Therapy of Atherosclerosis

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• 作者：Khalid Oumzil ; Michael A. Ramin ; Cyril Lorenzato ; Audrey Hémadou ; Jeanny Laroche ; Marie Josée Jacobin-Valat ; Stephane Mornet ; Claude-Eric Roy ; Tina Kauss ; Karen Gaudin ; Gisèle Clofent-Sanchez ; Philippe Barthélémy
• 刊名：Bioconjugate Chemistry
• 出版年：2016
• 出版时间：March 16, 2016
• 年：2016
• 卷：27
• 期：3
• 页码：569-575
• 全文大小：404K
• ISSN：1520-4812

文摘

Although the application of nanotechnologies to atherosclerosis remains a young field, novel strategies are needed to address this public health issue. In this context, the magnetic resonance imaging (MRI) approach has been gradually investigated in order to enable image-guided treatments. In this contribution, we report a new approach based on nucleoside-lipids allowing the synthesis of solid lipid nanoparticles (SLN) loaded with iron oxide particles and therapeutic agents. The insertion of nucleoside-lipids allows the formation of stable SLNs loaded with prostacycline (PGI2) able to inhibit platelet aggregation. The new SLNs feature better relaxivity properties in comparison to the clinically used contrast agent Feridex, indicating that SLNs are suitable for image-guided therapy.