Twilight Zone Sponges from Guam Yield Theonellin Isocyanate and Psammaplysins I and J

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• 作者：Anthony D. Wright ; Peter J. Schupp ; Jan-Philipp Schr枚r ; Anna Engemann ; Sven Rohde ; Dovi Kelman ; Nicole de Voogd ; Anthony Carroll ; Cherie A. Motti
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：March 23, 2012
• 年：2012
• 卷：75
• 期：3
• 页码：502-506
• 全文大小：204K
• 年卷期：v.75,no.3(March 23, 2012)
• ISSN：1520-6025

文摘

From the organic extracts of two Guam sponges, Rhaphoxya sp. and Suberea sp., determined to have cytotoxic and chemopreventive activities, three new compounds, theonellin isocyanate (1) and psammaplysins I and J (5, 6), and six previously reported compounds (2鈥?b>4, 7鈥?b>9) were isolated and characterized spectroscopically (¹H and ¹³C NMR, MS, IR, UV, [伪]_D). The two new metabolites (5 and 6) isolated from the Suberea sp. sponge are rare examples of compounds containing a bromotyramine moiety rather than the more usual dibromo analogue. For the compounds isolated from the Rhaphoxya sp., this is the first report of the known compounds 2鈥?b>4 being found in a single sponge. For previously reported compounds 2鈥?b>4 complete unambiguous ¹H and ¹³C NMR data are provided.