Design and Synthesis of Mimics of the T7-loop of FtsZ

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• 作者：Nohemy A. Sorto ; Phillip P. Painter ; James C. Fettinger ; Dean J. Tantillo ; Jared T. Shaw
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：June 7, 2013
• 年：2013
• 卷：15
• 期：11
• 页码：2700-2703
• 全文大小：280K
• 年卷期：v.15,no.11(June 7, 2013)
• ISSN：1523-7052

文摘

Mimics of the T7-loop of the bacterial cell division protein FtsZ have been designed and synthesized. The design is based on the X-ray cocrystal structure of P. aeruginosa FtsZ:SulA. Fast Rigid Exhaustive Docking (FRED) was employed to select compounds that can mimic the key interacting residues. Bicyclic oxazolidinones 1a鈥?b>d were selected for further study and synthesized from a key bicyclic aziridine intermediate, which is synthesized from a readily available unsaturated aldehyde and amides derived from 伪-amino acids.