Isolation, Structure Elucidation, and Antibacterial Activity of Methiosetin, a Tetramic Acid from a Tropical Sooty Mold (Capnodium sp.)
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- 作者：Kithsiri Herath ; Hiranthi Jayasuriya ; Deborah L. Zink ; Jan Sigmund ; Francisca Vicente ; Mercedes de la Cruz ; Angela Basilio ; Gerald F. Bills ; Jon D. Polishook ; Robert Donald ; John Phillips ; Michael Goetz ; Sheo B. Singh
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：March 23, 2012
- 年：2012
- 卷：75
- 期：3
- 页码：420-424
- 全文大小：206K
- 年卷期：v.75,no.3(March 23, 2012)
- ISSN：1520-6025
文摘
Drug-resistant bacteria continue to make many existing antibiotic classes ineffective. In order to avoid a future epidemic from drug-resistant bacterial infections, new antibiotics with new modes of action are needed. In an antibiotic screening program for new drug leads with new modes of action using antisense Staphylococcus aureus Fitness Test screening, we discovered a new tetramic acid, methiosetin, from a tropical sooty mold, Capnodium sp. The fungus also produced epicorazine A, a known antibiotic. The structure and relative configuration of methiosetin was elucidated by 2D NMR and ESIMS techniques. Methiosetin and epicorazine A showed weak to modest antibacterial activity against S. aureus and Haemophilus influenzae. The isolation, structure elucidation, and antibacterial activity of both compounds are described.