Transport Characteristics of a Novel Local Drug Delivery System Using Nordihydroguaiaretic Acid (NDGA)-Polymerized Collagen Fibers
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- 作者：Yvonne Moussy ; Eric Guegan ; Tian Davis ; Thomas J. Koob
- 刊名：Biotechnology Progress
- 出版年：2007
- 出版时间：August 2007
- 年：2007
- 卷：23
- 期：4
- 页码：990 - 994
- 全文大小：162K
- 年卷期：v.23,no.4(August 2007)
- ISSN：1520-6033
文摘
The use of nordihydroguaiaretic acid (NDGA)-polymerized collagen fibers as a novel local drugdelivery system is introduced. The drug loading of these biocompatible fibers is illustrated withthe anti-inflammatory agents dexamethasone and dexamethasone 21-phosphate. Capillary zoneelectrophoresis was used to measure the amount of drug released from the fibers into phosphatebuffered saline with time. From these measurements and the use of a mathematical model, wewere able to determine the diffusion coefficients for dexamethasone (D = 1.86 × 10-14 m2/s)and dexamethasone 21-phosphate (D = 2.36 × 10-13 m2/s) in the NDGA collagen fibers. Thesevalues have not been previously reported. These fibers can be used to load other agents as well.The diffusion coefficient of any agent loaded in these fibers can be determined using thetechniques and mathematical method described. The rate of drug release from the fibers can becontrolled using a PLGA coating. The overall importance of this paper is the potential broadapplication of this novel drug delivery system for the treatment of various human diseases.