Hollow Structured Y2O3:Yb/Er鈥揅uxS Nanospheres with Controllable Size for Simultaneous Chemo/Photothermal Therapy and Bioimaging

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• 作者：Ruichan Lv ; Piaoping Yang ; Fei He ; Shili Gai ; Guixin Yang ; Jun Lin
• 刊名：Chemistry of Materials
• 出版年：2015
• 出版时间：January 27, 2015
• 年：2015
• 卷：27
• 期：2
• 页码：483-496
• 全文大小：1046K
• ISSN：1520-5002

文摘

To integrate photothermal therapy (PTT) with chemotherapy for improved antitumor efficiency, we designed a novel multifunctional composite by attaching Cu_xS nanoparticles onto the surface of Y₂O₃:Yb/Er hollow spheres through a combined coprecipitation and subsequent hydrothermal route. By altering the initial pH values for the synthesis of precursors, the size and structure properties of the final composites can controllably be tuned. The conjugated folic acid (FA) makes the composite recognize the targeted cancer cells and the attached Cu_xS nanoparticles endow the composite with photothermal function. It is found that the release of doxorubicin (DOX) from the functional carrier could be triggered by both pH value and near-infrared (NIR) radiation. In particular, both PTT and chemotherapy can be simultaneously driven by 980 nm laser irradiation. The synergistic therapeutic effect based on PTT and chemotherapy can lead to low in vitro viability of 12.9% and highly strong inhibition of animal H22 tumor in vivo, which is superior to any individual therapy. Moreover, the composite exhibits the clear in vivo red up-conversion luminescence (UCL). This multifunctional nanocarrier can be applicable as bioimaging agent and effective antitumor agent for the synergistic interaction between PTT and the enhanced chemotherapy.