Synthesis, DNA Binding, and Cleaving Properties of an Ellipticine-Salen·Copper Conjugate
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- 作者：Sylvain Routier ; Jean-Luc Bernier ; Jean-Pierre Catteau ; Pierre Colson ; Claude Houssier ; Christian Rivalle ; Emile Bisagni ; and Christian Bailly
- 刊名：Bioconjugate Chemistry
- 出版年：1997
- 出版时间：November 1997
- 年：1997
- 卷：8
- 期：6
- 页码：789 - 792
- 全文大小：191K
- 年卷期：v.8,no.6(November 1997)
- ISSN：1520-4812
文摘
The synthesis of a DNA-cutting agent that conjugates anellipticine chromophore and a copper complexof bis(salicylidene)ethylenediamine, referred to as a salen,is reported. The presence of the salen·Cucomplex allows cleavage of DNA via oxygen-based radicals, and theellipticine moiety serves as aDNA anchor. Spectroscopic measurements indicate that theintercalation geometry of the ellipticinechromophore is preserved with the hybrid. The cleavage is muchmore efficient with the conjugatethan with the Schiff base copper complex alone.