Scalable in Situ Diazomethane Generation in Continuous-Flow Reactors

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• 作者：Emiliano Rossi ; Pierre Woehl ; Michele Maggini
• 刊名：Organic Process Research & Development
• 出版年：2012
• 出版时间：May 18, 2012
• 年：2012
• 卷：16
• 期：5
• 页码：1146-1149
• 全文大小：188K
• 年卷期：v.16,no.5(May 18, 2012)
• ISSN：1520-586X

文摘

Diazomethane is a valuable derivatizing agent but very difficult to handle for large-scale chemical transformations. We report here the base-induced decomposition of N-methyl-N-nitrosourea under continuous-flow conditions that enables the production up to 19 mol d^鈥? of diazomethane, at a total flow rate of 53 mL min^鈥?.