Micellization of Hydrophobically Modified Cyclodextrins. 1. Micellar Structure
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文摘
The grafting of a cholesterol derivative onto a methylated cyclodextrin through a spacer arm producesan amphiphilic compound exhibiting high solubility in water. This new molecule was fully characterizedin terms of chemical and optical purities by high resolution NMR and mass spectrometry. An analysis ofits behavior in aqueous solution using surface tension measurements and light, small-angle X-ray, andneutron scattering techniques proved that it self-assembles into monodisperse spherical micelles with anaverage aggregation number of 24. The micelles can be described as two-shell objects, the cyclodextrinmoieties being exposed to the aqueous medium, making them prone to include guest molecules in thecavities. These objects can therefore be of high interest for the targeting of biologically important moleculesand especially for the delivery of drugs.