Cycloartane Triterpenoids and Their Glycosides from the Rhizomes of Cimicifuga foetida

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• 作者：Ji-Yong Chen ; Ping-Lin Li ; Xu-Li Tang ; Shu-Jiang Wang ; Yong-Tao Jiang ; Li Shen ; Ben-Ming Xu ; Yong-Liang Shao ; Guo-Qiang Li
• 刊名：Journal of Natural Products
• 出版年：2014
• 出版时间：September 26, 2014
• 年：2014
• 卷：77
• 期：9
• 页码：1997-2005
• 全文大小：401K
• ISSN：1520-6025

文摘

A phytochemical study on the rhizomes of Cimicifuga foetida resulted in the isolation of two new cycloartane triterpenoids (1 and 2), eight new cycloartane glycosides (3鈥?b>10), and six known cycloartane glycoside analogues (11鈥?b>16). The structures of 1鈥?b>10 were determined by application of spectroscopic methods, with the absolute configuration of 1 determined by X-ray crystallography. Compounds 1鈥?b>6, as three pairs of epimers at C-10 and C-24, belong to a seven-membered-ring variant of 9,10-seco-9,19-cycloartane triterpenoids, and glycosides 3鈥?b>10 were found to be 3-O-尾-d-xylopyranosides. The cytotoxicity of the isolates was evaluated against five selected human tumor cell lines, and the known compounds 15 and 16 showed cytotoxicity against the hepatocellular carcinoma SMMC-7721 cell line with IC₅₀ values of 5.5 and 6.3 渭M, respectively.