Structure Elucidation and Biomimetic Synthesis of Hostasinine A, a New Benzylphenethylamine Alkaloid from Hosta plantaginea

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• 作者：Yue-Hu Wang ; Suo Gao ; Fu-Mei Yang ; Qian-Yun Sun ; Jun-Song Wang ; Hai-Yang Liu ; Chun-Shun Li ; Ying-Tong Di ; Shun-Lin Li ; Hong-Ping He ; Xiao-Jiang Hao
• 刊名：Organic Letters
• 出版年：2007
• 出版时间：December 6, 2007
• 年：2007
• 卷：9
• 期：25
• 页码：5279 - 5281
• 全文大小：115K
• 年卷期：v.9,no.25(December 6, 2007)
• ISSN：1523-7052

文摘

Hostasinine A (1), a benzylphenethylamine alkaloid with an unprecedented skeleton featuring a C-4-C-6 linkage and a nitrone moiety, wasisolated from Hosta plantaginea. Its structure was established on the basis of spectroscopic data, and was further confirmed by single-crystalX-ray diffraction. The alkaloid was postulated biogenetically from haemanthidine via N-oxidation and aza-aldol-type condensation and wassynthesized biomimetically. The inhibitory activities of 1 on acetylcholinesterase (AChE) and two tumor cell lines (K562 and A549) were alsoevaluated.