HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient

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• 作者：Maike Lichtenfels ; John Farrell ; Monday O. Ogese ; Catherine C. Bell ; Sidonia Eckle ; James McCluskey ; B. Kevin Park ; Ana Alfirevic ; Dean J. Naisbitt ; Munir Pirmohamed
• 刊名：Chemical Research in Toxicology
• 出版年：2014
• 出版时间：February 17, 2014
• 年：2014
• 卷：27
• 期：2
• 页码：175-177
• 全文大小：248K
• ISSN：1520-5010

文摘

HLA-A*31:01 is associated with carbamazepine (CBZ) hypersensitivity in Caucasian and Japanese populations. Herein, we show that HLA-A*31:01+ restricted the activation of carbamazepine-specific CD8⁺ T-cells, which provides an immunological basis for the genetic association. Furthermore, CD4⁺ T-cells were activated with carbamazepine in a HLA-DRB1*04:04-restricted manner, indicating that a common HLA haplotype may contribute to the multiclonal T-cell response seen in European patients with CBZ hypersensitivity.