Base-Catalyzed Feedback in the Urea−Urease Reaction

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• 作者：Gang Hu ; John A. Pojman ; Stephen K. Scott ; Magdalena M. Wrobel ; Annette F. Taylor
• 刊名：Journal of Physical Chemistry B
• 出版年：2010
• 出版时间：November 11, 2010
• 年：2010
• 卷：114
• 期：44
• 页码：14059-14063
• 全文大小：240K
• 年卷期：v.114,no.44(November 11, 2010)
• ISSN：1520-5207

文摘

The bell-shaped rate−pH curve coupled to production of base in the urea−urease reaction was utilized to give feedback-driven behavior: an acid-to-base pH clock (a kinetic switch), bistability and hysteresis between an acid/base state when the initial pH was adjusted by a strong acid, and aperiodic pH oscillations when the initial pH was adjusted by a weak acid in an open reactor. A simple model of the reaction reproduced most of the experimental results and provided insight into the role of self-buffering in the dynamics. This reaction suggests new possibilities in the development of biocompatible feedback to couple to pH-sensitive processes for bioinspired applications in medicine, engineering, or materials science.