Synthesis of Sulfones from Organozinc Reagents, DABSO, and Alkyl Halides

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• 作者：Benjamin N. Rocke ; Kevin B. Bahnck ; Michael Herr ; Sophie Lavergne ; Vincent Mascitti ; Christian Perreault ; Jana Polivkova ; Andrei Shavnya
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 3, 2014
• 年：2014
• 卷：16
• 期：1
• 页码：154-157
• 全文大小：334K
• ISSN：1523-7052

文摘

Organozinc reagents react with the SO₂ surrogate DABSO, and the resulting zinc sulfinate salts are alkylated in situ to afford sulfones. This transformation has a broad scope and is compatible with a wide range of structural motifs of medicinal chemistry relevance including nitrile, secondary carbamates, and nitrogen-containing heterocycles.