Bioactive Prenylogous Cannabinoid from Fiber Hemp (Cannabis sativa)

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• 作者：Federica Pollastro ; Orazio Taglialatela-Scafati ; Marco Allara虁 ; Eduardo Mun虄oz ; Vincenzo Di Marzo ; Luciano De Petrocellis ; Giovani Appendino
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：September 23, 2011
• 年：2011
• 卷：74
• 期：9
• 页码：2019-2022
• 全文大小：702K
• 年卷期：v.74,no.9(September 23, 2011)
• ISSN：1520-6025

文摘

The waxy fraction from the variety Carma of fiber hemp (Cannabis sativa) afforded the unusual cannabinoid 4, identified as the farnesyl prenylogue of cannabigerol (CBG, 1) on the basis of its spectroscopic properties. A comparative study of the profile of 4 and 1 toward metabotropic (CB₁, CB₂) and ionotropic (TRPV1, TRPV2, TRPM8, TRPA1) targets of phytocannabinoids showed that prenylogation increased potency toward CB₂ by ca. 5-fold, with no substantial difference toward the other end-points, except for a decreased affinity for TRPM8. The isolation of 4 suggests that C. sativa could contain yet-to-be-discovered prenylogous versions of medicinally relevant cannabinoids, for which their biological profiles could offer interesting opportunities for biomedical exploitation.