Developments in Meyers鈥?Lactamization Methodology: En Route to Bi(hetero)aryl Structures with Defined Axial Chirality
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- 作者：Svetlana Postikova ; Mohamad Sabbah ; Daniel Wightman ; Ich Tuan Nguyen ; Morgane Sanselme ; Thierry Besson ; Jean-Fran莽ois Bri猫re ; Sylvain Oudeyer ; Vincent Levacher
- 刊名：The Journal of Organic Chemistry
- 出版年：2013
- 出版时间：August 16, 2013
- 年：2013
- 卷：78
- 期：16
- 页码：8191-8197
- 全文大小：375K
- 年卷期：v.78,no.16(August 16, 2013)
- ISSN：1520-6904
文摘
Highly atroposelective Meyers鈥?lactamization promoted by pivalic acid under microwave irradiation is reported which allows the construction of nonracemic substituted-dibenzo(di)azepine derivatives through a center to axial chirality transfer principle, controlling the otherwise configurationally labile biaryl axis. This approach provides a straightforward entry to enantioenriched analogues of biorelevant architectures.