Formation of a Stable 14-Helix in Short Oligomers of Furanoid cis--Sugar-Amino Acid
详细信息 查看全文
- 作者：Srivari Chandrasekhar ; Marepally Srinivasa Reddy ; Bharatam Jagadeesh ; Anabathula Prabhakar ; Mallem H. V. Ramana Rao ; and Bulusu Jagannadh
- 刊名：Journal of the American Chemical Society
- 出版年：2004
- 出版时间：October 27, 2004
- 年：2004
- 卷：126
- 期：42
- 页码：13586 - 13587
- 全文大小：85K
- 年卷期：v.126,no.42(October 27, 2004)
- ISSN：1520-5126
文摘
Oligomers of a new class of sugar amino acids (SAA) using a xylofuranoic acid has been shown to generate a robust 14-helix. The design involved the use of xylofuranose with a cis arrangement between the amine and carboxyl groups to promote the adoption of a 14-helix instead of a mixed 12/10-helix observed in a sugar oligomer using a ribofuranoic acid and 
ges/gifchars/beta2.gif" BORDER=0 ALIGN="middle">-Ala. The observation of a stable right-handed 14-helix in a cis-SAA is unprecedented.