Silica-Supported Oligomeric Benzyl Phosphate (Si-OBP) and Triazole Phosphate (Si-OTP) Alkylating Reagents

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• 作者：Pradip K. Maity ; Saqib Faisal ; Alan Rolfe ; Diana Stoianova ; Paul R. Hanson
• 刊名：Journal of Organic Chemistry
• 出版年：2015
• 出版时间：October 16, 2015
• 年：2015
• 卷：80
• 期：20
• 页码：9942-9950
• 全文大小：640K
• ISSN：1520-6904

文摘

The syntheses of silica-supported oligomeric benzyl phosphates (Si-OBP_n) and triazole phosphates (Si-OTP_n) using ring-opening metathesis polymerization (ROMP) for use as efficient alkylating reagents is reported. Ease of synthesis and grafting onto the surface of norbornenyl-tagged (Nb-tagged) silica particles has been demonstrated for benzyl phosphate and triazole phosphate monomers. It is shown that these silica polymer hybrid reagents, Si-OBP_n and Si-OTP_n, can be used to carry out alkylation reactions with an array of different nucleophiles to afford the corresponding benzylated and (triazolyl)methylated products in good yield and high purity.