Chronic Dietary Kudzu Isoflavones Improve Components of Metabolic Syndrome in Stroke-Prone Spontaneously Hypertensive Rats

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• 作者：Ning Peng ; Jeevan K. Prasain ; Yanying Dai ; Ray Moore ; Alireza Arabshahi ; Stephen Barnes ; Scott Carlson ; J. Michael Wyss
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：2009
• 出版时间：August 26, 2009
• 年：2009
• 卷：57
• 期：16
• 页码：7268-7273
• 全文大小：749K
• 年卷期：v.57,no.16(August 26, 2009)
• ISSN：1520-5118

文摘

The present study tested the long-term effects of dietary kudzu root extract supplementation on the regulation of arterial pressure, plasma glucose, and circulating cholesterol in stroke-prone spontaneously hypertensive rats (SP-SHR). Female SP-SHR were maintained for 2 months on a polyphenol-free diet, with or without the addition of 0.2% kudzu root extract. Half of the rats in each diet group were ovariectomized, whereas the other half remained intact. Following 2 months on the diets, the 0.2% kudzu root extract supplementation (compared to control diet) significantly lowered arterial pressure (11−15 mmHg), plasma cholesterol, fasting blood glucose (20−30%), and fasting plasma insulin in both the ovariectomized and intact SP-SHR. These results indicate that long-term dietary kudzu root extract supplementation can improve glucose, lipid, and blood pressure control in intact and ovariectomized SP-SHR.